Yes, it is possible to change the image in a mesh while keeping the same mesh and physics constraints in Unity. You can achieve this by using linked meshes in Spine. Linked meshes allow you to share and reuse a single mesh with different images. You can set up linked meshes in Spine by creating a mesh and then linking it to different images. This way, you can switch images at runtime without altering the mesh or its physics properties. For more information on linked meshes, you can refer to the Spine User Guide on Linked Meshes.