@paulp We have just pushed a bugfix commit to the 4.2 branch which should fix this issue.
EsotericSoftware/spine-runtimes2574
You could integrate the shader changes of the above commit to your 4.1 package installation. Note that the commit fixes a second files, which is an include file used by the other URP 2D shader Universal Render Pipeline/2D/Spine/Sprite
.
You can also find the modified file for your 4.1 URP package below:
Please let us know if this fixes the issue for you as well.
Issue ticket URL for later reference:
EsotericSoftware/spine-runtimes2574