Hi, it seems that the combination is not correct between the settings which you made in your project settings and the shader which you set to your skeleton's material.
Universal Render Pipeline/Spine/Skeleton Lit can not be used with URP 2D Renderer. You seem to have a Global Light 2D in your scene, but if you want your skeleton to be affected by 2D lights, you need to use Universal Render Pipeline/2D/Spine/Skeleton Lit or Universal Render Pipeline/2D/Spine/Sprite.
If you want to use Universal Render Pipeline/Spine/Skeleton Lit rather than those shaders, then you need to replace the URP Asset and URP Asset_Render which are set in Project Settings - Graphics - Scriptable Render Pipeline Settings and Project Settings - Quality - Rendering, respectively.
